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Related Experiment Video

Updated: Jul 21, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

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Optical causes of experimental myopia.

J G Sivak¹, D L Barrie, M G Callender

¹School of Optometry, University of Waterloo, Ontario, Canada.

Ciba Foundation Symposium

|January 1, 1990

Summary

Experimental myopia in chicks is induced by degraded retinal images, primarily through vitreous chamber enlargement. This occurs regardless of optic nerve status, suggesting accommodation is not the main driver of induced myopia.

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Area of Science:

Ophthalmology
Developmental Biology
Animal Models

Background:

Induced myopia in chicks is a common experimental outcome.
Myopia development is linked to changes in the eye's vitreous chamber size.
The role of the cornea and accommodation in experimental myopia is debated.

Purpose of the Study:

To investigate the mechanisms underlying experimentally induced myopia in chicks.
To determine the contribution of the cornea and accommodation to myopia development.
To explore the eye's refractive adaptation to altered visual input.

Main Methods:

Chicks were reared with devices degrading the retinal image (translucent goggles).
Experimental myopia was induced using convex and concave soft contact lenses.
Morphological analysis of the ciliary muscle and accommodative apparatus was performed.

Main Results:

Degraded retinal images consistently induced myopia, mainly via vitreous chamber enlargement.
Corneal changes were inconsistent across studies, with no definitive role established.
Chick eyes adapted refractive states to match applied lens power, suggesting accommodative involvement, yet no morphological differences were found.

Conclusions:

Vitreous chamber enlargement is the primary cause of experimentally induced myopia in chicks.
Accommodation may play a role in refractive adaptation, but without apparent morphological changes in the ciliary muscle.
Further research is needed to fully elucidate the mechanisms of visual-feedback-driven eye growth.