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Experimental myopia in tree shrews.

¹Department of Physiological Optics, School of Optometry, The Medical Center, University of Alabama, Birmingham 35294.

Ciba Foundation Symposium

|January 1, 1990

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Form deprivation in tree shrews causes axial myopia, with potential recovery. Local mechanisms, not just retinal signals, contribute to myopia development and progression.

Area of Science:

Ophthalmology
Developmental Biology
Neuroscience

Background:

Postnatal visual deprivation reliably induces axial myopia in tree shrews.
This myopia is characterized by vitreous chamber elongation and other ocular changes.

Purpose of the Study:

To investigate the mechanisms underlying experimental myopia development in tree shrews.
To explore the role of retinal activity and scleral resistance in myopia progression and recovery.

Main Methods:

Monocular form deprivation using opaque goggles or eyelid suture.
Intravitreal injections of tetrodotoxin (TTX) to block action potentials.
Treatment with lathyritic agents to inhibit collagen cross-linking.

Main Results:

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Tetrodotoxin (TTX) injections did not prevent myopia, suggesting local retinoscleral contributions.
Lathyritic agents significantly exacerbated myopia, increasing vitreous chamber elongation and thinning the sclera.
Short periods of visual deprivation allowed for recovery, indicating plasticity.

Conclusions:

Experimental myopia in tree shrews involves complex interactions between ocular growth and internally driven expansion.
Retinal activity and scleral properties play crucial roles in regulating axial eye elongation.
Findings suggest potential therapeutic targets for myopia control by modulating these mechanisms.