Search for antifungal compounds from the wood of durable tropical trees

Alice M S Rodrigues1, Phellipe N E T Theodoro, Véronique Eparvier

  • 1CNRS, UMR ECOFOG, Université des Antilles et de la Guyane, 97300 Cayenne, France.

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Introduction to Wood01:19

Introduction to Wood

Wood, derived from trees, is a versatile and widely used construction material. Trees feature a trunk surrounded by a protective layer of dead bark. Beneath this outer layer lies the living bark, followed by the cambium, and then the sapwood which transitions into heartwood as it matures. At the center of the trunk is the pith. The age of a tree can be discerned by examining its growth rings, which are concentric bands visible in the trunk's cross-section.
The structural integrity of the wood...
Biodeterioration01:28

Biodeterioration

Biodeterioration refers to the unwanted alteration of materials caused by microorganisms—especially fungi—which damage both organic substrates (paper, wood, textiles) and inorganic ones (stone, plaster, glass). Unlike abiotic decay, biodeterioration results from biological activity that produces physical disruption and chemical degradation.Physical deterioration occurs as fungal hyphae penetrate pores, cracks, and surface irregularities. Hyphal turgor pressure, thigmotropic growth along...
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...