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Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
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Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

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Targeted agents in ovarian cancer

T S Kristedja1, R J Morgan, M Cristea

  • 1Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.

Women'S Health (London, England)
|October 5, 2010
PubMed

Insights

Targeted therapies show promise for ovarian cancer, offering new hope against disease recurrence. Ongoing trials explore novel agents like poly-ADP-ribose polymerase inhibitors for improved patient outcomes.

Area of Science:

  • Gynecologic Oncology
  • Medical Oncology
  • Pharmacology

Background:

  • Ovarian cancer frequently recurs despite treatment advances.
  • Targeted therapies have transformed other cancer care but lack FDA approval for ovarian cancer.
  • Existing Phase II data shows promise for targeted agents in ovarian cancer management.

Purpose of the Study:

  • To review the current landscape of targeted therapies for ovarian cancer.
  • To identify promising agents and future directions in ovarian cancer treatment.

Main Methods:

  • Review of existing clinical trial data (Phase II and III).
  • Analysis of targeted therapy classes including monoclonal antibodies, tyrosine kinase inhibitors, antiangiogenic agents, and poly-ADP-ribose polymerase inhibitors.
  • Discussion of ongoing research and development.

Main Results:

  • No targeted therapies are FDA-approved for ovarian cancer, but Phase II trials show potential.
  • Antiangiogenic agents are in Phase III trials for adjuvant and recurrent settings.
  • Poly-ADP-ribose polymerase inhibitors demonstrate promise, especially in BRCA1/2-mutated cancers, with ongoing trials.

Conclusions:

  • Targeted therapies represent a significant area of development for ovarian cancer.
  • Further research and clinical trials are crucial to realize the potential of these agents.
  • Future directions include combination therapies and agents targeting specific mutations.

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