Related Experiment Video
Updated: Jun 8, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Historical perspective on HIV‐exposed seronegative individuals: has nature done the experiment for us?
1Experimental immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Abstract:
Multiple and frequent exposure to the human immunodeficiency virus (HIV) does not necessarily result in HIV infection. Approximately 15% of HIV exposed seronegative individuals repeatedly resist infection, a phenomenon that has been observed in all investigated HIV‐exposed cohorts. This brief report provides a limited historic perspective of the discovery of these cohorts and outlines some of the immunologic and genetic parameters that are associated with resistance. We raise the possibility that assessing immunologic parameters of the phenomenon might provide insights that might be relevant for effective AIDS vaccine design.
More Related Videos
Related Concept Videos
Hypothesis: Accept or Fail to Reject?
There are two ways to indicate that the null hypothesis is not rejected. 'Accept' the null hypothesis and 'fail to...
Ethics in Research
Criticisms of the Evolutionary Perspective
Evolutionary psychology provides one explanation for these findings, suggesting...
What is an Experiment?
Retrovirus Life Cycles
Malaria

