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Related Experiment Video

Updated: Jun 8, 2026

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

Retinal angiomatous proliferation.

J Marticorena¹, V Di Leva, G L Cennamo

¹Instituto Tecnológico de Oftalmologia, Santiago de Compostela, Spain. jmarticorena@gmail.com

Current Drug Targets

|October 5, 2010

Summary

Retinal angiomatous proliferation (RAP), a form of wet age-related macular degeneration (AMD), presents a poor prognosis. Current treatments are varied, with combined therapies showing potential for improved outcomes and reduced recurrence.

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Area of Science:

Ophthalmology
Retinal diseases
Macular degeneration

Background:

Retinal angiomatous proliferation (RAP) is a distinct subtype of choroidal neovascularization.
It complicates wet age-related macular degeneration (AMD), accounting for 8-22% of new exudative AMD cases.
RAP predominantly affects elderly women and has a poor prognosis.

Purpose of the Study:

To review the clinical characteristics, prognosis, and established therapeutic strategies for RAP.
To discuss the potential benefits of combining different treatment modalities for RAP.

Main Methods:

Review of existing literature on Retinal Angiomatous Proliferation.
Analysis of therapeutic strategies including laser photocoagulation and anti-VEGF agents.
Discussion on the efficacy and recurrence rates of various treatment combinations.

Main Results:

RAP is characterized by a neovascular process with a high likelihood of forming disciform scars, leading to severe vision loss.
Treatment options are not standardized, ranging from laser photocoagulation to anti-VEGF therapies.
The origin of the neovascularization in RAP remains under discussion.

Conclusions:

Retinal angiomatous proliferation is an aggressive form of exudative AMD with a challenging prognosis.
Established treatments are evolving, and combination therapies may offer improved effectiveness and lower recurrence rates.
Further research is needed to establish optimal treatment protocols for RAP.