Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

Diagnostic and Statistical Manual of Mental Disorders (DSM)

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improving adherence and health outcomes in testicular cancer survivors using a mobile health-based intervention: A mixed-methods pilot study.

Digital health·2023

Same author

Effectiveness of sensory modulation for people with schizophrenia: A multisite quantitative prospective cohort study.

Australian occupational therapy journal·2022

Same author

Reply to Drs Almendra-Arao and Sotres-Ramos regarding Barnard's concept of convexity and possible extensions.

Pharmaceutical statistics·2020

Same author

MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue.

British journal of cancer·2017

Same author

Responding to challenges for people with psychotic illness: Updated evidence from the Survey of High Impact Psychosis.

The Australian and New Zealand journal of psychiatry·2016

Same author

Suicidal ideation and non-fatal deliberate self-harm presentations in the Kimberley from an enhanced police-mental health service notification database.

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists·2016

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Musculoskeletal disorders and comorbid depression: implications for practice.

Chris Lloyd¹, Geoff Waghorn, Cate McHugh

¹Division of Occupational Therapy, University of Queensland, St Lucia, Queensland, Australia. lloyd@onthenet.com.au

Australian Occupational Therapy Journal

|October 5, 2010

Summary

Depression significantly hinders return-to-work for individuals with work-related musculoskeletal disorders, leading to poorer occupational rehabilitation outcomes. Early detection and integrated treatment of depression are crucial for successful recovery and employment.

More Related Videos

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Related Experiment Videos

Last Updated: Jun 8, 2026

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Area of Science:

Occupational health
Psychiatry
Rehabilitation medicine

Background:

Work-related musculoskeletal disorders (WMSDs) are common and physically demanding.
Depression frequently co-occurs with WMSDs, impacting return-to-work (RTW) success.
Occupational rehabilitation faces pressure for timely and cost-effective RTW outcomes.

Purpose of the Study:

To investigate the impact of comorbid depression on RTW prospects for individuals with WMSDs.
To review existing evidence on depression's effect on labor force participation and rehabilitation outcomes.
To inform occupational rehabilitation practices regarding mental health integration.

Main Methods:

A comprehensive literature review was performed.
The review focused on studies examining depression in conjunction with WMSDs.
The analysis assessed effects on labor force participation and occupational rehabilitation outcomes.

Main Results:

Comorbid depression is associated with significant labor force disadvantage in working-age Australians with WMSDs.
Individuals with WMSDs and depression experience reduced RTW outcomes in occupational rehabilitation.
Population-level data highlight the negative economic and social impact of this comorbidity.

Conclusions:

Sufficient evidence exists to warrant integrating depression detection and treatment into occupational rehabilitation.
Proactive management of comorbid depression is essential to prevent rehabilitation failure.
Further research is needed, but current findings support immediate practice changes.