Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toxic effects of lead on neuronal development and function.

R Freedman1, L Olson, B J Hoffer

  • 1Department of Psychiatry, Denver Veterans Administration Medical Center, CO 80262.

Environmental Health Perspectives
|November 1, 1990
PubMed
Summary

Lead exposure harms nervous system development. Researchers developed a novel model to study lead

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Noradrenergic System of Aged GDNF Heterozygous Mice.

Cell transplantation·2017
Same author

Post-treatment with cocaine- and amphetamine-regulated transcript enhances infarct resolution, reinnervation, and angiogenesis in stroke rats - an MRI study.

NMR in biomedicine·2016
Same author

Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury.

Experimental neurology·2015
Same author

Enhanced survival of dopaminergic neuronal transplants in hemiparkinsonian rats by the p53 inactivator PFT-α.

Cell transplantation·2011
Same author

Adenoviral gene transfer of bone morphogenetic protein-7 enhances functional recovery after sciatic nerve injury in rats.

Gene therapy·2010
Same author

Transgenic rodent models of Parkinson's disease.

Acta neurochirurgica. Supplement·2008

Area of Science:

  • Neuroscience
  • Toxicology
  • Developmental Biology

Background:

  • Lead exposure is a significant public health concern, impacting nervous system development.
  • The precise mechanisms of lead-induced neurotoxicity remain unclear, hindering effective prevention and treatment.
  • The complexity of the brain and compensatory systems complicate the study of lead's effects on neuronal development.

Purpose of the Study:

  • To establish a model system for investigating the effects of lead on central nervous system development.
  • To overcome the challenges posed by the brain's complexity and compensatory mechanisms in studying neurodevelopmental toxicity.
  • To isolate specific neuronal development from systemic influences.

Main Methods:

  • Grafting discrete fetal rat brain regions into the anterior chamber of adult host eyes.
  • Utilizing an organotypic culture system within the anterior chamber of the eye.
  • Isolating brain tissue to prevent secondary systemic effects (endocrine, hematological) and transneuronal influences.

Main Results:

  • The model system allows for the study of neuronal development in isolation.
  • Potential to differentiate direct effects of lead from secondary systemic changes.
  • Facilitates investigation into lead's impact on specific brain regions without confounding factors.

Conclusions:

  • The developed model system offers a unique approach to studying lead's neurodevelopmental toxicity.
  • This method minimizes confounding variables, enabling a clearer understanding of lead's direct impact on neuronal development.
  • Further research using this model can elucidate mechanisms and inform prevention strategies for lead poisoning.

Related Experiment Videos