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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: Jun 8, 2026

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
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Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Published on: July 10, 2019

Brain imaging after neural transplantation.

Marios Politis1, Paola Piccini

  • 1Centre for Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital, Imperial College London, UK.

Progress in Brain Research
|October 5, 2010
PubMed
Summary

Functional imaging shows transplanted fetal cells can improve Parkinson's disease (PD) by releasing dopamine and restoring brain connections. However, graft-induced dyskinesias remain a challenge, requiring further investigation with imaging.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Regenerative Medicine

Background:

  • Human fetal ventral mesencephalic tissue transplantation shows promise for Parkinson's disease (PD).
  • Objective evidence of graft survival, dopamine release, and restored brain metabolism exists.
  • Clinical improvements were observed in open-label trials but not replicated in controlled trials.

Purpose of the Study:

  • To investigate the role of functional imaging in Parkinson's disease cell transplantation.
  • To understand mechanisms of graft-induced dyskinesias.
  • To explore functional imaging's utility in future clinical trials.

Main Methods:

  • Utilizing functional imaging techniques to assess transplanted tissue in PD patients.
  • Analyzing graft survival, dopamine release, and brain metabolism.
  • Investigating graft-induced dyskinesias and brain connectivity.

Main Results:

  • Functional imaging confirms graft survival, dopamine release, and restored striatal-cortical connections.
  • Graft-induced dyskinesias are identified as a significant adverse effect and roadblock.
  • Functional imaging can aid patient selection and monitor inflammatory processes.

Conclusions:

  • Functional imaging provides valuable insights into Parkinson's disease cell transplantation.
  • It can help elucidate mechanisms of adverse effects like dyskinesias.
  • While not a primary endpoint, functional imaging supports clinical trial development and patient monitoring.