Related Experiment Video
Updated: Jun 8, 2026

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry
Published on: May 17, 2016
The yin and yang of polycomb repression in regenerating muscle
Gergana Dobreva1, Thomas Braun
1Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Ludwigstr. 43, Germany.
Abstract:
Tumor necrosis factor-α (TNF-α) has complex effects on muscle regeneration. In this issue of Cell Stem Cell, Palacios et al. (2010) report that TNF-α-activated p38α kinase controls differentiation of muscle stem cells by promoting polycomb repressive complex 2 (PRC2) silencing of the Pax7 promoter.
Related Concept Videos
Master Transcription Regulators
Combinatorial Gene Control
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Formation of Muscle Fibers from Myoblasts
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...
Somatic to iPS Cell Reprogramming
Methods of Nuclear Reprogramming
Abnormal Proliferation

