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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
[Sepsis associated encephalopathy]
B Cretin1, N Collongues, N Philippi
1Département de neurologie, service de neuropsychologie, centre mémoire de ressources et de recherche d'Alsace, hôpitaux universitaires de Strasbourg, and UMR 7191, LINC, CNRS, université de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France. benjamin.cretin@chru-strasbourg.fr
Revue Neurologique
|October 5, 2010
Summary
Sepsis-associated encephalopathy (SAE) is a common cause of delirium resulting from infection. Early treatment of the infection and inflammation can lead to recovery or minimal consequences.
Area of Science:
- Neuroscience
- Infectious Diseases
- Critical Care Medicine
Context:
- Sepsis-associated encephalopathy (SAE) is a frequent complication of sepsis, presenting as delirium.
- SAE is characterized by diffuse cerebral dysfunction due to the body's systemic response to infection, excluding direct central nervous system infection.
- It is diagnosed by exclusion, highlighting the need for clear diagnostic criteria.
Purpose:
- To elucidate the underlying pathogenic mechanisms of SAE.
- To describe the clinical, biological, and radiological features for rapid identification of SAE.
- To emphasize the importance of timely management for improved patient outcomes.
Summary:
- SAE involves intense central nervous system inflammation and blood-brain barrier impairment.
- Clinical, biological, and radiological characteristics aid in SAE diagnosis.
- Despite severe prognosis, early intervention is crucial.
Impact:
- Improved understanding of SAE pathogenesis.
- Enhanced diagnostic capabilities for SAE.
- Potential for better patient outcomes through prompt and appropriate management of sepsis and its neurological complications.
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