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Related Experiment Video

Updated: Jun 8, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Neonatal renal tumours.

Mark Powis1

  • 1Department of Paediatric Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, LS1 3EX, United Kingdom. mark.powis@leedsth.nhs.uk

Early Human Development
|October 5, 2010
PubMed
Summary
This summary is machine-generated.

Neonatal renal tumors are rare, with mesoblastic nephroma being the most common. Treatment is typically surgical, with excellent survival rates for most types, except for malignant rhabdoid tumors.

Related Experiment Videos

Last Updated: Jun 8, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Area of Science:

  • Pediatric Oncology
  • Nephrology
  • Radiology

Background:

  • Neonatal renal tumors are uncommon, accounting for 7% of all neonatal malignancies.
  • Presentation often involves a flank mass or incidental detection via antenatal/postnatal ultrasound.
  • Mesoblastic nephroma is the predominant type, though Wilms' tumor and other neoplasms also occur.

Purpose of the Study:

  • To review the presentation, diagnosis, and management of neonatal renal tumors.
  • To highlight the importance of cross-sectional imaging in disease assessment.
  • To discuss treatment strategies and outcomes based on tumor type and clinical presentation.

Main Methods:

  • Review of existing literature on neonatal renal tumors.
  • Analysis of diagnostic imaging modalities, particularly cross-sectional imaging.
  • Discussion of treatment approaches including radical nephroureterectomy and chemotherapy indications.

Main Results:

  • Mesoblastic nephroma is the most frequent diagnosis in neonates.
  • Cross-sectional imaging effectively delineates tumor extent.
  • Radical nephroureterectomy is the primary treatment, with chemotherapy rarely needed.
  • Survival is generally favorable, with malignant rhabdoid tumors posing the poorest prognosis due to potential metastases.

Conclusions:

  • Neonatal renal tumors require prompt diagnosis and tailored management.
  • Surgical intervention is the mainstay of treatment for most cases.
  • Early detection and appropriate treatment lead to excellent survival outcomes for the majority of these rare tumors.