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Updated: Jun 8, 2026
Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
Surgical techniques and outcomes after anterior cruciate ligament reconstruction in preadolescent patients
Christopher C Kaeding1, David Flanigan, Christopher Donaldson
1Department of Orthopaedic Surgery, The Ohio State University Sports Medicine Center, 2050 Kenny Road, Columbus, OH 43221, U.S.A. Christopher.Kaeding@osumc.edu
Purpose:
To determine whether any anterior cruciate ligament (ACL) reconstruction technique is clinically superior in skeletally immature patients with wide-open physes.
Methods:
We searched Medline and Embase from 1966 to mid July 2009. Inclusion criteria required clinical studies of ACL reconstructions to define skeletally immature patients as having at least 1 of the following criteria: (1) chronologic age of less than 15 years in boys or less than 14 years in girls; (2) bone age of less than 15 years in boys or less than 14 years in girls; (3) Tanner stage I, II, or III; and (4) at least 10 cm of total growth after the reconstruction. Thirteen case series were identified and were evaluated for patient characteristics, surgical technique, clinical outcomes, and bone growth results.
Results:
Four studies used physeal-sparing techniques. Six studies used transphyseal techniques. Two studies used a combined technique, and a multicenter study reported results of both techniques. Within the physeal-sparing group, there were 2 studies that used an entirely extra-epiphyseal technique and 2 studies that used intra-epiphyseal techniques. Overall clinical outcomes were excellent, with growth complications being very rare in all of these series.
Conclusions:
Both physeal-sparing and transphyseal reconstructions can produce excellent clinical outcomes with a very low incidence of growth complications in Tanner stage II and III patients. Tanner stage I patients had excellent clinical results with physeal-sparing techniques (both extra- and intra-epiphyseal techniques). Not enough Tanner stage I patients underwent transphyseal techniques to support or discourage their use. This evidence supports considering the expansion of transphyseal reconstruction indications from Tanner stage IV patients to Tanner stage II and III patients. More studies evaluating transphyseal techniques in Tanner stage I patients are needed at this time.
Level Of Evidence:
Level IV, systematic review.