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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jun 8, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Comprehensive proteomics.

Martin Beck¹, Manfred Claassen, Ruedi Aebersold

¹European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany.

Current Opinion in Biotechnology

|October 5, 2010

Summary

This summary is machine-generated.

Achieving comprehensive proteome coverage is crucial for accurate biological comparisons. Recent technological advancements are making this goal more feasible for mass spectrometry-based proteomic studies.

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Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

Published on: November 13, 2021

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Last Updated: Jun 8, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

Published on: November 13, 2021

Area of Science:

Proteomics
Mass Spectrometry
Genomics

Background:

Current proteome discovery projects identify proteins for 50-70% of gene models.
Comprehensive proteome coverage is essential for unbiased quantitative comparisons.

Purpose of the Study:

To discuss the feasibility of achieving comprehensive proteome coverage.
To evaluate recent technological developments in mass spectrometry for proteomics.

Main Methods:

Review of recent technological advancements in mass spectrometry.
Analysis of proteome discovery project data.

Main Results:

Proteome discovery projects have achieved 50-70% coverage of predicted gene models.
Technological developments are improving the feasibility of comprehensive proteome coverage.

Conclusions:

Comprehensive proteome coverage is increasingly achievable.
Advancements in mass spectrometry are key to enhancing proteomic data comparison.