Tailored α-methylene-γ-butyrolactones and their effects on growth suppression in pancreatic carcinoma cells
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P Veeraraghavan Ramachandran1, Debarshi Pratihar, Hari Narayanan G Nair
1Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907-2084, United States. chandran@purdue.edu
Abstract:
A selected series of racemic α-methylene-γ-butyrolactones (AMGBL) were synthesized via allylboration and screened against three human pancreatic cancer cell lines (Panc-1, MIA PaCa-2, and BxPC-3). This systematic study established a discernible relationship between the substitution pattern of AMGBL and their anti-proliferative activity. β,γ-diaryl-AMGBLs, particularly those with a trans-relationship exhibited higher potency than parthenolide and LC-1 against all three cell lines.
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