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Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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The empirical approach to drug therapy optimization relies on correlating pharmacological response with administered dosage. Such an approach can be costly, time-consuming, and often yields poor correlation due to variables like formulation factors and drug elimination characteristics. A more precise approach correlates response with plasma drug concentration or the amount of drug in the body, rather than dosage. This is achieved through pharmacokinetic-pharmacodynamic (PK/PD) modeling, which...

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Prodrugs

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Updated: Jun 8, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Codrug: an efficient approach for drug optimization.

N Das¹, M Dhanawat, B Dash

¹Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221 005, Uttar Pradesh, India. nirupam.das.phe05@itbhu.ac.in

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences

|October 5, 2010

Summary

This summary is machine-generated.

Codrugs, or mutual prodrugs, combine drugs to overcome limitations and improve therapeutic properties. This strategy enhances drug delivery and efficacy by leveraging synergistic actions or targeted delivery.

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High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

High-throughput Identification of Synergistic Drug Combinations by the Overlap² Method

Published on: May 21, 2018

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Last Updated: Jun 8, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

High-throughput Identification of Synergistic Drug Combinations by the Overlap² Method

Published on: May 21, 2018

Area of Science:

Pharmaceutical Sciences
Medicinal Chemistry
Drug Delivery Systems

Background:

Effective drugs often possess drawbacks like poor solubility or targeted delivery challenges.
Codrugs offer a strategy to modify existing therapeutics by linking them with other pharmacophores.
This approach aims to mitigate limitations and enhance the overall therapeutic profile of drugs.

Purpose of the Study:

To explore the concept and applications of codrugs (mutual prodrugs) in pharmaceutical research.
To highlight the benefits of combining pharmacophores for improved drug properties.
To discuss the role of codrugs in enhancing physicochemical, biopharmaceutical, and drug delivery characteristics.

Main Methods:

Literature review on codrug design and synthesis strategies.
Analysis of case studies demonstrating codrug efficacy.
Examination of the impact of codrugs on drug properties.

Main Results:

Codrugs can be formed by direct linkage or through a connecting moiety.
Combining pharmacophores can lead to synergistic pharmacological effects.
This approach significantly improves physicochemical and biopharmaceutical properties, facilitating targeted drug delivery.

Conclusions:

Codrug strategy is a valuable approach for overcoming drug limitations.
It enhances drug efficacy, targeting, and delivery properties.
Further research into codrugs holds promise for advanced therapeutic agents.