Related Experiment Video
Updated: Jun 8, 2026
04:42
Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Prolidase activity and its diagnostic performance in bipolar disorder
Salih Selek1, Abdurrahman Altindag, Gulben Saracoglu
1Psychiatry Department, Medical School, Harran University, S.Urfa, Turkey. drselek@yahoo.com
Journal of Affective Disorders
|October 5, 2010
Summary
Serum prolidase activity was significantly higher in individuals with bipolar disorder (BD), suggesting it may serve as a diagnostic marker. This finding could link BD to oxidative stress pathways.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- Proline plays a key role in brain function.
- Prolidase, an enzyme that splits proline and is implicated in oxidative stress, has not been studied in bipolar disorder (BD).
Purpose of the Study:
- To investigate serum prolidase activity in patients with bipolar disorder compared to healthy controls.
- To explore the potential of prolidase activity as a biomarker for BD.
Main Methods:
- Serum prolidase activity was measured in 66 patients with BD type I and 66 healthy controls.
- Patients were further analyzed in subgroups: euthymic, manic, and depressive.
Main Results:
- Prolidase activity was significantly elevated in BD patients compared to controls (p<0.001).
- No significant differences in prolidase activity were observed among euthymic, manic, and depressive subgroups (p=0.305).
- A cutoff point of 502.9375 U/L demonstrated high diagnostic utility with a positive predictive value of 98.5% and negative predictive value of 92.4%.
Conclusions:
- Elevated prolidase activity in BD suggests a potential link to oxidative stress mechanisms.
- Prolidase activity may function as a trait marker for the diagnosis of bipolar disorder.
Related Concept Videos
01:30Bipolar Disorder
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
01:24Mania and Antimanic Drugs: Overview
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
01:26Psychosis: Goals of Pharmacotherapy
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...