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Updated: Jun 8, 2026
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
In vitro antitumor activity of N-glycosyl sulfonamides
Rosana Crespo1, Margarita G de Bravo, Pedro A Colinas
1Instituto de Investigaciones Bioquímicas de La Plata (UNLP-CONICET CCT La Plata), 60 y 120. (1900) La Plata, Argentina.
Abstract:
A series of α-D-hex-2-enopyranosyl sulfonamides was evaluated for their antiproliferative activity against human hepatocellular liver carcinoma (HepG2) and human lung adenocarcinoma (A549) cell lines. The most potent compound (2,4,6-tri-O-acetyl-3-deoxy-α-D-erythro-hex-2-enopyranosyl ethanesulfonamide) showed antiproliferative properties in the micromolar range. The SARs of these sulfonamidoglycoside which includes the influence of carbohydrate rings and sulfonamide class are described.
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