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Updated: Jun 8, 2026
05:41
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
[Intestinal microbiota in short bowel syndrome]
1Department of Pediatric Gastroenterology, Hepatology and Nutrition, Hospital Necker-Enfants Malades, University of Paris-Descartes, Paris, France. olivier.goulet@nck.aphp.fr
Gastroenterologie Clinique Et Biologique
|October 5, 2010
Summary
Short bowel syndrome (SBS) can lead to small intestine bacterial overgrowth (SIBO), impacting nutrient absorption and potentially causing liver disease. Managing SIBO in SBS patients requires careful consideration due to diagnostic and therapeutic challenges.
Area of Science:
- Gastroenterology and Hepatology
- Pediatric Surgery
- Microbiology
Context:
- Short bowel syndrome (SBS) is a primary cause of intestinal failure, particularly in pediatric populations.
- Extensive small bowel resection necessitates the colon's role in adaptation and function.
- SBS patients are highly susceptible to small intestine bacterial overgrowth (SIBO).
Purpose:
- To highlight the challenges in diagnosing and managing SIBO in SBS patients.
- To discuss the impact of SIBO on digestive/absorptive functions and TPN weaning.
- To explore SIBO's contribution to intestinal failure-associated liver disease (IFALD).
Summary:
- SIBO significantly impairs digestive and absorptive capabilities in SBS, hindering TPN weaning.
- SIBO is implicated in the pathogenesis of IFALD, potentially necessitating liver transplantation.
- Current diagnostic methods for SIBO in SBS may lack reliability.
- Antibiotic therapy for SIBO in SBS is debated; probiotics show promise but require more human data.
Impact:
- Improved understanding of SIBO's complex role in SBS pathophysiology.
- Informing clinical practice regarding SIBO diagnosis and management strategies in SBS.
- Guiding future research into effective SIBO treatments for SBS patients, including probiotics.
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