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Updated: Jun 8, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
11:10

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

Published on: December 27, 2010

HIV/AIDS in 3 generations: case series

Regina E Oladokun1, Emmanuel Adejokun, Biobele J Brown

  • 1Department of Paediatrics, University College Hospital, Ibadan, Nigeria. ginaoladokun@yahoo.com

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)
|October 5, 2010
PubMed

Insights

Generational HIV transmission is a reality, impacting families across multiple generations. This highlights the urgent need for comprehensive prevention and care strategies to combat the human immunodeficiency virus (HIV) pandemic.

Area of Science:

  • Epidemiology
  • Public Health
  • Genetics

Background:

  • The human immunodeficiency virus (HIV) pandemic poses a significant global health challenge.
  • Effective prevention, treatment, and care are crucial to mitigate generational impact.

Observation:

  • Three families were studied, with two exhibiting third-generation HIV infection, likely due to mother-to-child transmission.
  • Mothers and grandmothers across all families were HIV-positive, with a history of risky sexual behavior.
  • Children in one family were HIV-negative, serving as a control group.

Findings:

  • HIV infection can persist and transmit across multiple generations within families.
  • Maternal transmission is a key factor in generational HIV spread.
  • Affected children face compounded vulnerabilities due to family circumstances and parental illness or death.

Implications:

  • The long-standing nature of HIV/AIDS necessitates intergenerational care models.
  • Significant health and socioeconomic burdens affect families with multi-generational HIV infection.
  • Public health strategies must address the long-term, familial consequences of HIV/AIDS.
Abstract

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