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Related Concept Videos

Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...
Seizures ll: Types01:19

Seizures ll: Types

Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.

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Functional outcome after convulsive status epilepticus.

Stéphane Legriel1, Elie Azoulay, Matthieu Resche-Rigon

  • 1Intensive Care Department, Centre Hospitalier de Versailles, André Mignot Hospital, Le Chesnay, France. slegriel@ch-versailles.fr

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|October 5, 2010
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Summary
This summary is machine-generated.

Outcomes for convulsive status epilepticus (CSE) in the ICU are poor, with half of survivors experiencing severe disability. Early neuroprotection is suggested to improve functional recovery in CSE patients.

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Area of Science:

  • Neurology
  • Critical Care Medicine
  • Neuroscience

Background:

  • Convulsive status epilepticus (CSE) is a neurological emergency.
  • Limited data exist on long-term functional outcomes for CSE patients managed in intensive care units (ICUs).

Purpose of the Study:

  • To investigate 90-day functional outcomes in patients with CSE.
  • To identify factors associated with poor outcomes in CSE patients.

Main Methods:

  • A prospective observational cohort study included 248 CSE patients admitted to 18 ICUs.
  • Functional outcome was assessed using the Glasgow Outcome Scale (GOS) at 90 days.
  • Statistical analysis identified factors independently associated with poor outcomes (GOS < 5).

Main Results:

  • 18.8% of patients died, and 38.8% had severe functional impairments by day 90.
  • Refractory CSE, longer seizure duration, cerebral insult, and focal neurological signs were associated with poor outcomes.
  • Older age also correlated with worse functional status.

Conclusions:

  • Half of CSE survivors experience significant functional impairments 90 days post-ICU admission.
  • Early intervention and neuroprotective strategies may be crucial for improving outcomes.
  • Identifying and mitigating risk factors like prolonged seizures and refractory CSE is essential.