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A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
Differentiation of benign and malignant uterine corpus tumors by using proton MR spectroscopy at 3T: preliminary
Mayumi Takeuchi1, Kenji Matsuzaki, Masafumi Harada
1Department of Radiology, University of Tokushima, 3-18-15, Kuramoto-cho, zip:7708503 Tokushima, Japan. mayumi@clin.med.tokushima-u.ac.jp
Objective:
To retrospectively evaluate the diagnostic ability of magnetic resonance (MR) spectroscopy for distinguishing benign and malignant lesions in patients with uterine corpus tumours at MR imaging.
Methods:
Pelvic MR spectroscopy was performed in patients with pathologically diagnosed benign and malignant uterine corpus tumours at 3T-MR imaging. Single-voxel MR spectroscopy data were collected from a single square volume of interest that encompassed the uterine corpus lesion. The total choline compounds (tCho) resonance peak areas were quantified relative to unsuppressed water using a software package. Patients who fulfilled the criteria for estimates of acceptable reliability were included.
Results:
A total of 32 patients (age range, 24-76 years) with 32 lesions were evaluated in this study. The median lesion size at MR imaging was 50 mm (range, 19-218 mm). A tCho peak was present in all 32 lesions including 14 malignant lesions (9.21 ± 2.21 mM), and 18 benign lesions (4.59 ± 2.22 mM) (p < 0.0001). Using a cut-off value of 7.00 mM for malignant lesions had a sensitivity of 93%, specificity of 83%, PPV of 81% and NPV of 94%.
Conclusion:
Proton MR spectroscopy with quantitative evaluation of tCho concentration can provide helpful information in distinguishing benign and malignant uterine corpus tumours.
