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MAO-B inhibition in rabbit tissues and in human platelets by Ro 19-6327 shows similar time-course
R Kettler1, A M Cesura, J Dingemanse
1Pharmaceutical Department F. Hoffmann-La Roche Ltd. Basel, Switzerland.
Journal of Neural Transmission. Supplementum
|January 1, 1990
Abstract:
In rabbits, 3 mg/kg Ro 19-6327 p.o., induced complete monoamine oxidase type B (MAO-B) inhibition in striatum, cerebral cortex, liver and platelets for about 12 h. In healthy human volunteers complete inhibition of platelet MAO was obtained with only 5 mg Ro 19-6327. After 40 and 200 mg Ro 19-6327 the duration of complete MAO-B inhibition was prolonged to 12 and 24 hours, respectively. Changes in brain MAO-B in humans after Ro 19-6327 are likely to be faithfully reflected by platelet MAO activity.