Related Experiment Videos
Coronary risk factors in angiographically defined patients with chest pain
T Fujinami1, H Hirata, J Hayano
1Third Department of Internal Medicine, Nagoya City University Medical School, Japan.
Insights
Early intervention for lipid metabolism disorders is crucial. Correcting high cholesterol in individuals under 55 can reduce coronary sclerosis index (CSI), indicating less severe coronary artery narrowing.
Area of Science:
- Cardiology
- Preventive Medicine
- Biochemistry
Background:
- Coronary artery disease (CAD) is a leading cause of mortality.
- Lipid metabolism disorders are significant risk factors for CAD.
- Early identification of coronary atherosclerosis is vital for prevention.
Purpose of the Study:
- To assess coronary risk factors in relation to coronary artery narrowing.
- To investigate the correlation between lipid profiles and coronary sclerosis index (CSI).
- To determine age-specific thresholds for lipid management in preventing coronary atherosclerosis.
Main Methods:
- Coronary angiography was performed on 186 patients.
- Coronary sclerosis index (CSI) was calculated to quantify luminal narrowing.
- Patients were categorized into normal coronary arteries, coronary sclerosis without myocardial infarction (MI), and previous MI groups.
- Multivariate analysis was used to identify significant risk factors.
Main Results:
- CSI increased with age.
- Significant differences in triglycerides, HDL cholesterol, and atherogenic index were found between patients with and without coronary sclerosis.
- In patients under 55, high total and LDL cholesterol levels were associated with significantly higher CSI.
- In patients 55 and over, CSI correlated with age, blood sugar, factor H, and HDL cholesterol.
Conclusions:
- Lipid metabolism disorders are strongly associated with coronary atherosclerosis.
- Intervention to correct lipid abnormalities, particularly high cholesterol, is recommended in early middle age (under 55) to mitigate coronary artery narrowing.
- Age-specific risk factor management is essential for effective cardiovascular disease prevention.
Abstract:
Coronary risk factors were assessed in 186 consecutive patients who received coronary angiography. The severity of coronary luminal narrowing was scored as the coronary sclerosis index (CSI). Patients were divided into normal coronary arteries (N, n = 72), coronary sclerosis without infarction (C, n = 73) and previous myocardial infarction (MI, n = 41). The CSI increased with age. A significant difference in serum triglycerides, HDL cholesterol and atherogenic index was observed between Groups C or MI and N. Multivariate analysis revealed that CSI had correlated with total- and HDL-cholesterol, uric acid and age in subjects under 55 years; and with age, blood sugar, factor H and HDL cholesterol in those of 55 years or over. When patients were classified by their total and LDL cholesterol level, a significantly different CSI was found between the desirable and high cholesterol levels in subjects under the age of 55, but it was not significant in those over 55. Therefore, disorders in lipid metabolism should be corrected in early middle age.