[The effects of uneven fractionated irradiation on mouse squamous cell carcinoma and normal tissue]

In uneven fractionated radiotherapy combining large doses and small doses, we studied the influence of the order of their combination on tumors and on normal tissues, using squamous cell carcinoma and skin reaction of mice. The number of fractions was 6, and we used various combinations of 4 small doses and 2 large doses (4 times larger). The antitumor effect was smallest when a large dose was given at the end of treatment, but in skin reactions, there was no difference in effect even when the order of the combination of large and small doses was changed.