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Clonidine patch toxicity
1Department of Pharmacy Practice, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907.
Insights
Clonidine patch toxicity in children is a growing concern due to increased use of these transdermal systems. Early recognition and supportive care are crucial for managing pediatric poisoning from clonidine patches.
Area of Science:
- Pediatric Toxicology
- Pharmacology
- Emergency Medicine
Background:
- Transdermal clonidine delivery systems are increasingly used.
- Accidental pediatric exposure to clonidine patches can lead to severe toxicity.
- Case reports highlight the need for awareness of clonidine patch toxicity in children.
Abstract:
Five published case reports of clonidine patch toxicity in pediatric patients bring to light the importance of educating the public regarding appropriate use and disposal of transdermal drug-delivery systems. With the increasing use of clonidine transdermal delivery systems it is important that clonidine patch toxicity be considered in pediatric patients presenting with symptoms of depressed consciousness, miosis, hypoventilation, hypotension, bradycardia, hypothermia, cardiac dysrhythmias, hypotonia, or convulsions. Appropriate early supportive management is essential to avoid serious morbidity or mortality in the pediatric patient, and is reviewed herein.