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Polyanhydrides. V. Branched polyanhydrides.

M Maniar1, X D Xie, A J Domb

  • 1Nova Pharmaceutical Corporation, Baltimore, MD 21224-2788.

Biomaterials
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

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Branched polyanhydrides exhibit higher molecular weights and faster degradation than linear polymers. Drug release profiles varied, with poly(acrylic acid) branched polymers showing higher initial release, but overall approaching linear polymer behavior.

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomaterials

Background:

  • Polyanhydrides are a class of biodegradable polymers with potential applications in drug delivery.
  • Branching can significantly alter polymer properties, including molecular weight, degradation, and drug release kinetics.

Purpose of the Study:

  • To synthesize and characterize branched polyanhydrides using sebacic acid with 1,3,5 benzenetricarboxylic acid and poly(acrylic acid) as branching agents.
  • To compare the physico-chemical properties, degradation behavior, and drug release profiles of branched polyanhydrides with their linear counterparts.

Main Methods:

  • Synthesis of random and graft-type branched polyanhydrides via polymerization.
  • Evaluation of molecular weight, specific viscosity, physico-chemical properties, and thermal behavior.

Related Experiment Videos

  • Assessment of degradation rates and drug release kinetics using morphine as a model drug.

    • Main Results:

    • Branched polyanhydrides achieved significantly higher molecular weights (250,000 Da) compared to linear poly(sebacic anhydride) (80,000 Da).
    • Branched polyanhydrides showed faster, triphasic degradation rates than linear polymers.
    • Morphine release was generally lower from branched polyanhydrides, with poly(acrylic acid) branched polymers exhibiting higher initial release.

    Conclusions:

    • Branching effectively increases polyanhydride molecular weight without significantly altering thermal or physico-chemical properties.
    • Branched polyanhydrides demonstrate altered degradation and drug release profiles compared to linear analogs.
    • The choice of branching agent influences drug release, offering tunable properties for specific applications.