Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autosomal and X-chromosome imprinting.

B M Cattanach1, C V Beechey

  • 1MRC Radiobiology Unit, Chilton, Didcot, Oxon, UK.

Development (Cambridge, England). Supplement
|January 1, 1990
PubMed
Summary

Genomic imprinting in mice reveals that specific chromosome regions are functionally different based on parental origin, impacting embryonic development and survival. These imprinting effects are crucial for normal development and are observed across several chromosomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A pedigree-based genetic appraisal of Boxer ARVC and the role of the Striatin mutation.

The Veterinary record·2015
Same author

Interactions between imprinting effects: summary and review.

Cytogenetic and genome research·2006
Same author

Imprinting control within the compact Gnas locus.

Cytogenetic and genome research·2006
Same author

A reassessment of imprinting regions and phenotypes on mouse chromosome 6: Nap1l5 locates within the currently defined sub-proximal imprinting region.

Cytogenetic and genome research·2004
Same author

Microarray expression profiling of tissues from mice with uniparental duplications of chromosomes 7 and 11 to identify imprinted genes.

Mammalian genome : official journal of the International Mammalian Genome Society·2001
Same author

Genetic, physical, and phenotypic characterization of the Del(13)Svea36H mouse.

Mammalian genome : official journal of the International Mammalian Genome Society·2001

Area of Science:

  • Developmental Biology
  • Genetics
  • Epigenetics

Background:

  • Parental germ line imprinting affects autosomal loci, making maternal and paternal gene copies functionally distinct.
  • Imprinted gene expression is critical for mammalian development, influencing embryonic and fetal growth.

Purpose of the Study:

  • To identify and characterize autosomal regions subject to genomic imprinting in mice.
  • To understand the consequences of imprinting errors on embryonic development and survival.

Main Methods:

  • Utilizing mouse genetic studies with Robertsonian and reciprocal translocations.
  • Analyzing effects of duplicated maternal/paternal copies and deficient paternal/maternal copies in zygotes.

Main Results:

  • Identified 8-9 chromosomal regions exhibiting imprinting effects, primarily on chromosomes 2, 7, and 17.
  • Observed a spectrum of developmental outcomes, from embryonic lethality to viable offspring with phenotypic effects.
  • Confirmed X chromosome imprinting, including paternal X-inactivation in extra-embryonic tissues and maternal X-inactivation in female somatic cells.

Conclusions:

  • Genomic imprinting is a significant epigenetic mechanism regulating mammalian development.
  • Imprinting errors can lead to severe developmental defects and lethality.
  • Further research is needed to confirm imprinting on chromosomes 1, 5, 9, and 14.

Related Experiment Videos