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Influence of new quinolones on normal immune capabilities
A F Tawfik1, H A Shoeb, S J Bishop
1Department of Pharmaceutics and Microbiology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Abstract:
Ciprofloxacin, pefloxacin, norfloxacin, and ofloxacin were investigated for immunomodulatory activity on humoral and cell-mediated immune responses. Ciprofloxacin and pefloxacin altered the humoral immune responses of mice to sheep red blood cells. This effect was not exhibited by norfloxacin or ofloxacin. All four quinolones did not alter cell-mediated responses. When these antimicrobial agents were tested for their interaction with human polymorphonuclear phagocytic activity, all agents suppressed this activity. In addition, all except norfloxacin showed anti-inflammatory activity.
Insights
Certain fluoroquinolones like ciprofloxacin and pefloxacin impact humoral immunity in mice, while all tested quinolones suppress human immune cell activity and exhibit anti-inflammatory effects, except for norfloxacin.
Area of Science:
- Immunology
- Pharmacology
- Microbiology
Background:
- Fluoroquinolones are broad-spectrum antibiotics.
- Their immunomodulatory effects require further investigation.
Purpose of the Study:
- To evaluate the immunomodulatory activity of ciprofloxacin, pefloxacin, norfloxacin, and ofloxacin.
- To assess their impact on humoral and cell-mediated immunity, phagocytic activity, and inflammation.
Main Methods:
- In vivo studies on mice immune responses to sheep red blood cells.
- In vitro assessment of human polymorphonuclear phagocytic activity.
- Evaluation of anti-inflammatory properties.
Main Results:
- Ciprofloxacin and pefloxacin modulated humoral immune responses in mice; norfloxacin and ofloxacin did not.
- No significant alteration in cell-mediated immune responses was observed for any quinolone.
- All tested fluoroquinolones suppressed human polymorphonuclear phagocytic activity.
- Ciprofloxacin, pefloxacin, and ofloxacin demonstrated anti-inflammatory activity, while norfloxacin did not.
Conclusions:
- Specific fluoroquinolones possess immunomodulatory and anti-inflammatory properties.
- These findings highlight potential interactions between fluoroquinolones and the immune system.
- Further research is warranted to elucidate the clinical implications of these observed effects.