Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibiotic prophylaxis in gynecological surgery.

G C Oliva1, A Fratoni, L Papadia

  • 1Ist. Clinica Ostetrica e Ginecologica, Università Cattolica del Sacro Cuore, Rome, Italy.

Journal of Chemotherapy (Florence, Italy)
|October 1, 1990
PubMed
Summary

This study compared mezlocillin and cefotetan, two broad-spectrum antibiotics, for gynecological surgery. Both antibiotics demonstrated comparable effectiveness in preventing surgical site infections, showing no significant differences in outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing knee diagnostics and treatment: the role of needle arthroscopy.

Musculoskeletal surgery·2025
Same author

"Mushrooms (and a cow) are A Means of Survival for Us": Dissimilar Ethnomycological Perspectives among Hutsuls and Romanians Living Across The Ukrainian-Romanian Border.

Environmental management·2022
Same author

Just beautiful green herbs: use of plants in cultural practices in Bukovina and Roztochya, Western Ukraine.

Journal of ethnobiology and ethnomedicine·2021
Same author

Practice recommendations for neurovascular ultrasound investigations of acute stroke patients in the setting of the COVID-19 pandemic: an expert consensus from the European Society of Neurosonology and Cerebral Hemodynamics.

European journal of neurology·2020
Same author

Combining olfactory test and motion analysis sensors in Parkinson's disease preclinical diagnosis: a pilot study.

Acta neurologica Scandinavica·2017
Same author

[Pilot study of professional exposure and hearing functionality of orchestra musicians of a national lyric theatre].

Giornale italiano di medicina del lavoro ed ergonomia·2008

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Pharmacology

Background:

  • Surgical site infections are a significant concern in gynecological procedures.
  • Prophylactic antibiotic administration is crucial for preventing postoperative infections.

Purpose of the Study:

  • To compare the efficacy of mezlocillin and cefotetan as prophylactic antibiotics in elective gynecological surgery.
  • To evaluate the effectiveness of these two broad-spectrum antibiotics in achieving optimal therapeutic levels during surgery.

Main Methods:

  • A randomized prospective study was conducted involving 184 patients undergoing abdominal or vaginal hysterectomy.
  • Patients received either mezlocillin or cefotetan (2 g IV) 15-20 minutes preoperatively.
  • Outcomes were assessed to determine the effectiveness of each antibiotic in preventing infections.

Related Experiment Videos

Main Results:

  • No statistically significant differences were observed in the effectiveness between mezlocillin and cefotetan.
  • Both antibiotics achieved optimal serum and tissue levels, contributing to infection prevention.

Conclusions:

  • Mezlocillin and cefotetan are equally effective prophylactic antibiotics for patients undergoing elective gynecological surgery.
  • The choice between mezlocillin and cefotetan can be based on other factors, as efficacy is comparable.