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Evaluation of the Contraves Autolyzer 801
Y C Lim1, S K Cheong, J A Joyce
1Division of Haematology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur.
The Malaysian Journal of Pathology
|June 1, 1990
Summary
The Contraves Autolyzer 801 cell counter shows good precision and linearity for most parameters. Minor calibration biases were noted for white blood cell (WBC), hematocrit (Hct), and platelet (Plt) counts.
Area of Science:
- Hematology
- Clinical Laboratory Science
- Medical Device Evaluation
Background:
- Automated hematology analyzers are crucial for efficient blood cell counting.
- The Contraves Autolyzer 801 is a 20-parameter impedance-based cell counter.
- Evaluating new analyzers ensures accuracy and reliability in diagnostic testing.
Purpose of the Study:
- To assess the performance and reliability of the Contraves Autolyzer 801.
- To evaluate its precision, linearity, and correlation with established methods.
- To identify any potential biases or limitations in its operation.
Main Methods:
- Within-batch precision analysis for key parameters (WBC, RBC, Hb, Hct, Plt).
- Reproducibility testing of red cell parameters over time.
- Linearity assessment across the analyzer's range.
- Comparative analysis against Coulter S-Plus and M350 analyzers.
- Correlation with manual Packed Cell Volume (PCV) method.
Main Results:
- Coefficients of variation below 5% for WBC, RBC, Hb, Hct, and Plt.
- Reproducible red cell counts for up to 3 days.
- Good linearity demonstrated for all parameters.
- Negligible carry-over in red cell parameters.
- Proportional and constant bias detected in WBC, Hct, and Plt due to calibration.
Conclusions:
- The Contraves Autolyzer 801 offers good precision and linearity for most parameters.
- Minor calibration issues require attention for WBC, Hct, and Plt.
- The analyzer is user-friendly and generally correlates well with other methods.