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Micronutrient supplements: toxicity and drug interactions.

N W Flodin1

  • 1Department of Biochemistry, College of Medicine, University of South Alabama, Mobile 36688.

Progress in Food & Nutrition Science
|January 1, 1990
PubMed
Summary

Self-prescribed micronutrient supplements can lead to toxicity and dangerous drug interactions, especially in older adults. This review highlights risks associated with excessive vitamin and trace element intake.

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Area of Science:

  • Nutritional Science
  • Geriatric Medicine
  • Pharmacology

Background:

  • Increasing self-prescription of single micronutrients at pharmacologic doses.
  • Potential for chronic toxicity and adverse drug interactions.
  • Elderly population most affected due to high supplement use and polypharmacy.

Purpose of the Study:

  • To review the toxicity of commonly self-prescribed micronutrients.
  • To examine potential adverse interactions between micronutrients and medications.
  • To address concerns specific to the elderly population.

Main Methods:

  • Literature review of toxicity data for 13 vitamins.
  • Review of toxicity data for trace elements: chromium, selenium, and zinc.
  • Analysis of reported drug-nutrient interactions.

Main Results:

  • Excessive intake of certain vitamins and trace elements can cause chronic toxicity.
  • Significant potential for adverse interactions with both prescription and over-the-counter drugs.
  • Elderly individuals face heightened risks due to multiple health conditions and medications.

Conclusions:

  • Self-prescribed high-dose micronutrients pose significant health risks, including toxicity and drug interactions.
  • Medical supervision is crucial, particularly for the elderly, to mitigate these risks.
  • Further research is needed to fully elucidate the scope of these interactions.

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