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[A multicenter study comparing nitrendipine and chlorthalidone in elderly hypertensive patients]
F Guillén Llera1, J C Caballero, J L Guijarro
1Servicio de Geriatría, Hospital de la Cruz Roja, Madrid.
Revista Clinica Espanola
|September 1, 1990
Summary
Nitrendipine effectively controlled hypertension in elderly patients, achieving therapeutic goals in 92.4% of cases. Combined with chlorthalidone, it further improved outcomes with minimal side effects, enhancing overall treatment success.
Area of Science:
- Cardiology
- Geriatrics
- Pharmacology
Background:
- Hypertension is a prevalent condition in elderly populations.
- Effective antihypertensive management is crucial for reducing cardiovascular risk in older adults.
- Exploring monotherapy versus combination therapy for hypertension in the elderly is essential.
Purpose of the Study:
- To evaluate the efficacy and safety of nitrendipine and chlorthalidone in treating low-to-moderate hypertension in elderly patients.
- To compare monotherapy with combination therapy using nitrendipine and chlorthalidone.
- To assess the impact of these treatments on patients' quality of life.
Main Methods:
- A 4-month study involving 111 elderly patients with low-to-moderate hypertension.
- Patients were treated with either nitrendipine or chlorthalidone monotherapy, or a combination, based on therapeutic response.
- Blood pressure, biochemical parameters, and quality of life were monitored.
Main Results:
- Nitrendipine monotherapy achieved the therapeutic goal (diastolic blood pressure < 95 mmHg) in 92.4% of patients, significantly higher than chlorthalidone (49.1%).
- By the study's end, 96.3% of all patients reached the therapeutic goal.
- Adverse events were low across all treatment groups (8.3% for nitrendipine, 6.1% for chlorthalidone, 11.1% for combination).
Conclusions:
- Nitrendipine demonstrates superior efficacy as monotherapy for elderly hypertension compared to chlorthalidone.
- Combination therapy further enhances blood pressure control in this population.
- Both drugs are well-tolerated with no significant adverse effects on blood biochemistry or quality of life.