[Transient elevation in immunity in a senile female patient]

A case of an 85 year old female patient who during an infectious episode developed multiple autoimmune markers, autoantibodies, hypergammaglobulinemia, bicytopenia, hemolytic anemia, and cryoglobulinemia is described. All the anomalies disappeared during the following four weeks and during this period the patient presented no clinical manifestations. The hypothesis is that the infectious stimulus provoked a markedly exaggerated response. We highlight the rareness of this out of proportion transitory and silent immune response, emphasizing the greater cell sensibility to different stimuli in older patients.