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Published on: December 29, 2016
[Affective disorders in the chronic phase of ischemic cerebrovascular disease]
A Arboix1, L Mauri, J L Martí-Vilalta
1Servicio de Neurología, Hospital de la Santa Creu i Sant Pau, Barcelona.
Insights
Affective disorders, such as depression, are common in patients with chronic ischemic cerebral vascular disease (ICVD). Early diagnosis and treatment are crucial for improving patient outcomes.
Area of Science:
- Neurology
- Psychiatry
- Vascular Neurology
Context:
- Ischemic cerebral vascular disease (ICVD) significantly impacts patient well-being.
- Affective disorders are frequently observed in the chronic phase of ICVD.
Purpose:
- To determine the incidence and characteristics of affective disorders in patients with chronic ICVD.
- To identify factors associated with the occurrence of affective disorders in this population.
Summary:
- Thirty-nine percent of patients with chronic ICVD exhibited affective disorders.
- Depression rates were highest in atherothrombotic and cardioembolic infarcts, and lowest in lacunar infarcts.
- Factors like prior depression history, infarct extent, location (carotid territory, dominant hemisphere, cortical), and severity of functional limitation were associated with higher affective disorder incidence.
Impact:
- Highlights the significant prevalence of affective disorders in chronic ICVD.
- Underscores the necessity of accurate diagnosis and appropriate treatment for affective disorders in ICVD patients.
- Aims to improve clinical symptom management and overall patient prognosis in chronic ICVD.
Abstract:
Thirty-nine percent (33/83) of patients in this study present affective disorders in the chronic phase of ischemic cerebral vascular disease (ICV). The incidence of depression reaches its maximum in atherothrombotic infarcts (52%, 15/29) and in infarcts of cardiac embolic origin (71%, 5/7), and its minimum in lacunar infarcts (25%, 11/43). Affective disorders are more common (27%) in patients with previous history of depression (p = 0.005) and they are more common when the infarcts are extensive (87%, 7/8), they are located in the carotid territory (42%, 25/59), in the dominant cerebral hemisphere (60%, 20/33) and they are more frequent at cortical level (55%, 15/27) (p = 0.03), mainly when they produce a clinical situation with moderate (50%, 10/20) or severe (87%, 7/8) (p = 0.006) limitation. Our results demonstrate that affective disorders are frequent in the chronic phase of ischemic cerebral vascular disease and it is mandatory its correct diagnosis in order to perform an adequate treatment and to improve the clinical symptoms of these patients.
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