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[Chorea and systemic lupus erythematosus].

J Antolín1, M J Amérigo, E Gómez

  • 1Servicio de Medicina Interna, Hospital Virgen del Pino, Las Palmas.

Revista Clinica Espanola
|November 1, 1990
PubMed
Summary

Chorea is a rare manifestation of systemic lupus erythematosus. Antiphospholipid antibodies may play a role in its development via thrombotic or autoimmune mechanisms.

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Area of Science:

  • Neurology
  • Rheumatology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations.
  • Chorea, a hyperkinetic movement disorder, is an exceptionally rare neurological complication of SLE.
  • Recent studies suggest a link between SLE, antiphospholipid antibodies, and neurological dysfunction.

Observation:

  • This report details a case of chorea in a female patient diagnosed with systemic lupus erythematosus.
  • The patient presented with involuntary, purposeless, rapid movements characteristic of chorea.
  • The clinical presentation prompted an investigation into potential underlying mechanisms related to SLE.

Findings:

  • The patient exhibited a greater frequency of circulating anticoagulants and antiphospholipid antibodies, common in SLE.

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  • These findings support the hypothesis that antiphospholipid antibodies may contribute to chorea development in SLE patients.
  • Potential pathogenic mechanisms include thrombotic events or autoimmune encephalitis mediated by these antibodies.

    • Implications:

    • This case highlights the importance of considering chorea as a rare neurological manifestation of SLE.
    • The findings underscore the potential role of antiphospholipid antibodies in SLE-associated chorea, suggesting a thrombotic or autoimmune encephalitis pathway.
    • Further research is warranted to elucidate the precise mechanisms linking SLE, antiphospholipid antibodies, and chorea, potentially informing diagnostic and therapeutic strategies.