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Mutagenesis as viewed from another perspective.

M Lieber

    Rivista Di Biologia
    |January 1, 1990
    PubMed
    Summary
    This summary is machine-generated.

    Mutation is not always random; genetic mutator systems allow for adaptively directed mutagenesis in response to environmental stress. This broadens the definition of mutagens and mutagenic processes in biology.

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    Area of Science:

    • Genetics
    • Evolutionary Biology
    • Molecular Biology

    Background:

    • Traditionally, mutation is viewed as a random, undirected process.
    • Adaptively responsive mutagenesis, where mutations are directed by environmental cues, has been conceptually excluded.
    • Genetic mutator systems, known for years, have been considered exceptional rather than integral to adaptive responses.

    Purpose of the Study:

    • To challenge the paradigm of mutation as purely random.
    • To explore the role of genetic mutator systems in adaptively directed mutagenesis.
    • To broaden the definition of mutagens and mutagenic processes.

    Main Methods:

    • Conceptual analysis of existing knowledge on mutation and genetic systems.
    • Review of literature on genetic mutator systems and their potential role in adaptive responses.

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  • Discussion of environmental stress as a potential trigger for directed mutagenesis.

    • Main Results:

    • Genetic mutator systems can facilitate adaptively directed mutagenesis in response to environmental stress.
    • The concept of what constitutes a mutagenic agent needs to be expanded.
    • Previously overlooked genetic systems are implicated in adaptive mutagenesis.

    Conclusions:

    • Mutation can be an adaptively responsive process, not solely random.
    • Environmental stress can directly influence the direction of genetic change through mutator systems.
    • A revised understanding of mutagenesis is required to incorporate directed, adaptive mechanisms.