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Pharmacokinetics of eltoprazine in healthy subjects
J van Harten1, I S Mathlener, M Raghoebar
1Duphar B.V., Drug Disposition Department, Weesp, The Netherlands.
Drug Metabolism and Drug Interactions
|January 1, 1990
Abstract:
The pharmacokinetics of eltoprazine in healthy male subjects was investigated after intravenous and oral dosing in one study, and after oral dosing of 14C-eltoprazine in a second study. It was shown that the absorption of eltoprazine from the gastro-intestinal tract was complete, and that absolute bioavailability was 100%. The mean elimination half-life of eltoprazine in plasma was about 8 hours. Approximately 40% of the dose was excreted unchanged in urine.