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Updated: Jun 8, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
[Neuroendocrine changes in patients with inflammatory diseases and colonic cancer]
Abstract:
The study included 60 patients of whom 20 presented with colonic cancer, 20 with ulcerative colitis UC), and 20 with Crohn's disease (CD). Control group was comprised of 20 healthy subjects. It was shown that UC and CD can be regarded as apudopathies based on reduced melatonin production associated with altered proliferative activity, apoptosis, and accumulation of free radicals. UC and CD patients with high p53, PCNA, and oxidative stress levels both with and without dysplasia of intestinal epithelium are at risk of developing colonic cancer and require efficacious preventive treatment with early diagnosis of oncological problems.
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