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Subjective cognitive complaints and longitudinal changes in memory and brain function.

Timothy J Hohman1, Lori L Beason-Held, Melissa Lamar

  • 1Laboratory of Personality and Cognition, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard,Suite 100, Baltimore, MD 21224, USA.hohmantj@mail.nih.gov

Neuropsychology
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Summary
This summary is machine-generated.

Subjective cognitive complaints predict faster memory decline and altered brain activity in older adults. These findings support the use of cognitive complaints as markers for age-related memory and brain changes.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Gerontology

Background:

  • Subjective cognitive complaints are frequently used in diagnosing cognitive impairment.
  • Understanding the link between complaints and objective measures is crucial for early detection.

Purpose of the Study:

  • To investigate the association between subjective cognitive complaints and longitudinal cognitive changes.
  • To examine cross-sectional differences in brain function during memory tasks in relation to cognitive complaints.

Main Methods:

  • The Cognitive Failures Questionnaire (CFQ) assessed subjective cognitive complaints.
  • Mixed effects regression models analyzed longitudinal cognitive changes over 11.5 years.
  • Positron Emission Tomography (PET) measured regional cerebral blood flow during memory tasks.

Main Results:

  • Higher cognitive complaints (CFQ scores) correlated with steeper declines in verbal learning and recall.
  • Increased brain activity in insular, lingual, and cerebellar regions was observed during memory tasks with higher cognitive complaints.
  • These brain activity changes were evident during both resting and active memory states.

Conclusions:

  • Subjective cognitive complaints appear to be valid indicators of age-related memory decline.
  • Cognitive complaints are associated with measurable changes in brain activity during cognitive tasks.
  • These findings support the clinical utility of subjective cognitive complaints in assessing cognitive aging.