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Updated: Jun 8, 2026

Human Saphenous Vein Endothelial Cell Isolation and Exposure to Controlled Levels of Shear Stress and Stretch
Published on: April 21, 2023
"Go with the flow": how Krüppel-like factor 2 regulates the vasoprotective effects of shear stress
Lalitha Nayak1, Zhiyong Lin, Mukesh K Jain
1Division of Hematology/Oncology, Department of Medicine, Case Western Reserve University School of Medicine, University Hospitals, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Abstract:
Laminar shear stress is known to confer potent anti-inflammatory, antithrombotic, and antiadhesive effects by differentially regulating endothelial gene expression. The identification of Krüppel-like factor 2 as a flow-responsive molecule has greatly advanced our understanding of molecular mechanisms governing vascular homeostasis. This review summarizes the current understanding of Krüppel-like factor 2 action in endothelial gene expression and function.
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