Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteomic and Phosphoproteomic Characterization of Disease-Associated Alterations in Nerve Terminals and Protein Inclusions of Alzheimer's Disease Patients.

Journal of proteome research·2026
Same author

Modeling Synaptic Maturation From Growth Cone to Synapse in Human Organoids.

Journal of neurochemistry·2026
Same author

Single-nucleus brain transcriptomics reveals microglia dysfunction in multiple system atrophy.

Nature communications·2026
Same author

Multi-omic analysis of guided and unguided forebrain organoids reveals differences in cellular composition and metabolic profiles.

Cell reports methods·2026
Same author

Adjusting PSC culture for neural organoid generation.

Stem cell reports·2025
Same author

Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons.

NPJ Parkinson's disease·2025

Related Experiment Video

Updated: Jun 8, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

[Stem cell therapy for neurodegenerative disorders].

Morten Meyer1, Pia Jensen, Jens Zimmer Rasmussen

  • 1Neurobiologisk Forskning, Institut for Molekylaer Medicin, Syddansk Universitet, Winsløwparken 21 st., 5000 Odense C, Denmark.

Ugeskrift for Laeger
|October 6, 2010
PubMed
Summary

Neural stem cell therapy shows promise for Parkinson's and Huntington's disease by replacing lost cells. Further development of standardized cell lines is crucial for widespread clinical application in neurodegenerative diseases.

More Related Videos

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
06:12

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

Related Experiment Videos

Last Updated: Jun 8, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
06:12

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Context:

  • Intrastriatal fetal neural transplants offer symptomatic relief for Parkinson's and Huntington's diseases.
  • Current cell therapy approaches do not halt the underlying neurodegenerative process.
  • Significant challenges impede the widespread clinical adoption of cell-based therapies for neurodegenerative conditions.

Purpose:

  • To review the current state and future potential of cell therapy in neurodegenerative diseases.
  • To highlight the need for standardized and safe cell sources for clinical application.
  • To discuss the expected advancements in cell replacement and trophic factor production.

Summary:

  • Fetal neural transplants can improve symptoms in Parkinson's and Huntington's disease patients but do not stop primary cell loss.
  • Advancements in standardized master cell lines from human embryonic stem cells, induced pluripotent stem cells, and neural stem cells are critical.
  • These improved cell sources are anticipated for cell replacement therapies and producing therapeutic factors within years.

Impact:

  • Facilitates the development of advanced cell therapies for neurodegenerative disorders.
  • Accelerates the transition of stem cell research from laboratory to clinical practice.
  • Paves the way for novel treatments targeting neuroprotection and regeneration.