Mercuric chloride inhibition of leucocyte migration

The effects of mercuric chloride, at different concentrations, were tested on polymorphonuclear and mononuclear leucocyte migration by using the sealed capillary migration technique, and these effects were compared to influence on cell number and dye exclusion. A migration inhibition was obtained at 1.1 x 10(-5) M when tested on polymorphonuclear cells, while a concentration of 6.6 x 10(-5) inhibited the migration of mononuclear cells. Polymorphonuclear cells seemed to be more sensitive (were inhibited at a lower dose) to mercuric chloride as regards migration compared to cell number and dye exclusion, while mononuclear cells showed migration inhibition at about the same dose range as that which had effect on dye exclusion and cell number.