Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Questionable association between mechanical power and ventilator-induced lung injury in acute respiratory distress syndrome.

American journal of respiratory and critical care medicine·2026
Same author

Initial non-invasive in vivo sensing of the lung using time domain diffuse optics.

Scientific reports·2024
Same author

Extensive Nonsegmental Pulmonary Perfusion Defects on SPECT/CT as an Early Sign of COVID-19 Infection.

World journal of nuclear medicine·2022
Same author

Assessment of Ventilation and Perfusion in Patients with COVID-19 Discloses Unique Information of Pulmonary Function to a Clinician: Case Reports of V/P SPECT.

Clinical medicine insights. Circulatory, respiratory and pulmonary medicine·2021
Same author

Imaging for precision medicine: can V-P SPECT measure mepolizumab response in asthma?

Respirology case reports·2021
Same author

Tidal Volume Lowering by Instrumental Dead Space Reduction in Brain-Injured ARDS Patients: Effects on Respiratory Mechanics, Gas Exchange, and Cerebral Hemodynamics.

Neurocritical care·2020

Related Experiment Video

Updated: Jun 8, 2026

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent
08:26

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent

Published on: June 5, 2019

Methodology for ventilation/perfusion SPECT.

Marika Bajc1, Brian Neilly, Massimo Miniati

  • 1Department of Clinical Physiology, Lund University Hospital, Lund University, Lund, Sweden. marika.bajc@med.lu.se

Seminars in Nuclear Medicine
|October 6, 2010
PubMed
Summary
This summary is machine-generated.

Ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) effectively diagnoses pulmonary embolism. A holistic interpretation strategy, considering all patient data and V/Q patterns, is recommended over probabilistic methods for accurate diagnosis.

More Related Videos

Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment
05:56

Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment

Published on: August 9, 2024

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
12:29

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Published on: May 30, 2011

Related Experiment Videos

Last Updated: Jun 8, 2026

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent
08:26

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent

Published on: June 5, 2019

Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment
05:56

Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment

Published on: August 9, 2024

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
12:29

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Published on: May 30, 2011

Area of Science:

  • Nuclear Medicine
  • Radiology
  • Pulmonary Imaging

Background:

  • Ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) is crucial for diagnosing pulmonary embolism (PE) and other lung disorders.
  • Technegas shows advantages over radiolabeled liquid aerosols, even without obstructive lung disease.
  • Radiolabeled macroaggregated human albumin is the standard for perfusion scintigraphy.

Purpose of the Study:

  • To outline an optimal protocol for V/Q SPECT imaging.
  • To advocate for a holistic interpretation strategy for V/Q SPECT.
  • To highlight the diagnostic capabilities of V/Q SPECT beyond PE.

Main Methods:

  • Optimized nuclide activities, acquisition times, collimators, and imaging matrix for a ~20-minute V/Q SPECT study.
  • Recommended protocol involves the patient remaining in an unchanged position for ventilation and perfusion scans.
  • Utilizes matching ventilation/perfusion slices in all projections and rotating volume images.

Main Results:

  • Achieves adequate V/Q SPECT studies in approximately 20 minutes.
  • Enables presentation of matching ventilation and perfusion slices and volume images.
  • Identifies PE through V/Q mismatch in subsegments representing anatomic lung units.

Conclusions:

  • V/Q SPECT is a valuable tool for diagnosing PE and other lung pathologies like obstructive disease, heart failure, and pneumonia.
  • A holistic interpretation strategy is superior to probabilistic methods for V/Q SPECT.
  • Awareness of imaging technique and interpretation pitfalls is essential for accurate V/Q SPECT studies.