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Maternal diabetes and risk of esophageal atresia

Jenny Oddsberg1, Yunxia Lu, Jesper Lagergren

  • 1Department of Molecular Medicine and Surgery, Upper Gastrointestinal Research, Karolinska Institutet, SE-171 76 Stockholm, Sweden. jenny.oddsberg@karolinska.se

Journal of Pediatric Surgery
|October 6, 2010
PubMed

Insights

Maternal diabetes may increase the risk of esophageal atresia in infants. This study found a 70% higher risk in children born to mothers with diabetes, highlighting a potential link in congenital malformations.

Area of Science:

  • Pediatric congenital malformations
  • Reproductive endocrinology and diabetes

Background:

  • The causes of esophageal atresia remain largely unknown.
  • Maternal diabetes is linked to other congenital anomalies, but its specific role in esophageal atresia is unclear.

Purpose of the Study:

  • To investigate the association between maternal diabetes and the risk of esophageal atresia in infants.

Main Methods:

  • A population-based, matched case-control study was conducted using data from neonates born in Sweden between 1982 and 2007.
  • Conditional logistic regression and multivariable regression were employed to calculate adjusted odds ratios and control for confounding factors.

Main Results:

  • The study included 780 cases of esophageal atresia and 7,800 controls.
  • Infants of mothers with pre-existing or gestational diabetes had a 70% increased risk of esophageal atresia (OR, 1.7; 95% CI, 1.0-2.9).
  • Maternal diabetes exposure was more frequent in the case group (2.3%) compared to the control group (1.3%).

Conclusions:

  • Maternal diabetes is a potential risk factor for the development of esophageal atresia in offspring.
  • Further research is warranted to elucidate the mechanisms underlying this association.
Abstract

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