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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Acute pancreatitis induced by ifosfamide therapy
Rajan Garg1, Sandeep Agarwala, Veereshwar Bhatnagar
1Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi-110029, India. rajangarg1985@gmail.com
Ifosfamide chemotherapy can cause acute pancreatitis in children with solid tumors. Promptly investigating abdominal pain and stopping ifosfamide leads to complete recovery from this rare adverse effect.
Area of Science:
- Oncology
- Pediatric Oncology
- Pharmacology
Background:
- Ifosfamide is a chemotherapy agent used for pediatric solid tumors.
- Serious adverse effects are associated with ifosfamide treatment.
- Acute pancreatitis is a rare but serious complication of ifosfamide therapy.
Observation:
- This report details a case of acute pancreatitis in a young girl undergoing treatment for recurrent Wilms tumor.
- The patient received a chemotherapy regimen including ifosfamide, carboplatin, and etoposide.
- Abdominal pain is a common symptom in cancer patients but often underinvestigated.
Findings:
- The patient developed acute pancreatitis during ifosfamide-based chemotherapy.
- Discontinuation of ifosfamide resulted in complete recovery without lasting effects.
- This case highlights a rare adverse event associated with ifosfamide.
Implications:
- Patients receiving ifosfamide require careful monitoring for signs of acute pancreatitis.
- Prompt investigation of abdominal pain in these patients is crucial.
- Withholding ifosfamide typically leads to full recovery from pancreatitis.
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