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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: Jun 8, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Cancer epigenome.

Matthias Lechner1, Chris Boshoff, Stephan Beck

  • 1UCL Cancer Institute, University College London, London, UK.

Advances in Genetics
|October 6, 2010
PubMed
Summary
This summary is machine-generated.

Cancer arises from genetic and epigenetic changes, often influenced by environmental factors. Comprehensive genomic and epigenomic analysis is key to identifying cancer-causing alterations and advancing personalized cancer treatment.

More Related Videos

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Related Experiment Videos

Last Updated: Jun 8, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Area of Science:

  • Oncology
  • Genomics
  • Epigenetics

Background:

  • Cancer is a complex disease driven by genomic and epigenomic abnormalities.
  • These alterations include genetic mutations, genomic rearrangements, and epigenetic changes like DNA methylation and histone modifications.
  • Environmental and lifestyle factors can mediate these epigenetic changes.

Purpose of the Study:

  • To review recent advancements in cancer genomics and epigenomics.
  • To discuss pilot studies integrating epigenomic analysis into cancer research.
  • To highlight the role of these analyses in personalized cancer treatment.

Main Methods:

  • Comprehensive genetic analysis of cancer genomes.
  • Epigenomic profiling, including DNA methylation and histone modification analysis.
  • Review of existing pilot studies in the field.

Main Results:

  • Pilot studies demonstrate the value of epigenomic analysis in cancer research.
  • Genomic and epigenomic analyses are crucial for identifying tumorigenesis drivers.
  • These analyses are essential for understanding inherited and acquired cancer-related changes.

Conclusions:

  • Epigenomic analysis is an integral component of modern cancer research.
  • Understanding cancer's genetic and epigenetic landscape is vital for personalized medicine.
  • Future cancer treatment will increasingly rely on comprehensive genomic and epigenomic insights.