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Eoxins: a new inflammatory pathway in childhood asthma
Christine Sachs-Olsen1, Marek Sanak, Astri Maria Lang
1Department of Paediatrics, Oslo University Hospital, Oslo, Norway. c.sachs@online.no
The Journal of Allergy and Clinical Immunology
|October 6, 2010
Summary
The 15-lipoxygenase (LO) pathway, producing eicosanoids like 15-hydroxyeicosatetraenoic acid (15-HETE) and eoxins, is active in childhood asthma. These eicosanoids in exhaled breath condensate (EBC) correlate with asthma and bronchial hyperresponsiveness (BHR).
Area of Science:
- Biochemistry
- Pulmonology
- Pediatrics
Background:
- Leukotrienes (LTs) in exhaled breath condensate (EBC) are linked to asthma and bronchial hyperresponsiveness (BHR).
- The role of eicosanoids from the 15-lipoxygenase (LO) pathway, including 15-hydroxyeicosatetraenoic acid (15-HETE) and eoxins, in childhood asthma remains less understood.
Purpose of the Study:
- To investigate the association between 5-LO and 15-LO pathway metabolites in EBC and childhood asthma.
- To determine if these metabolites correlate with asthma severity and clinical parameters in children.
Main Methods:
- Analysis of 131 school-aged children (asthmatic and healthy controls) and 19 with chronic lung disease.
- Clinical assessments including spirometry, fractional exhaled nitric oxide, skin prick testing, and methacholine challenge.
- Quantification of eicosanoids in EBC using mass spectrometry, reported as concentrations and ratios to palmitic acid (PA).
Main Results:
- Significantly elevated ratios of eoxin C₄/PA, eoxin D₄/PA, eoxin E₄/PA, 15-HETE/PA, and LTC₄/PA in asthmatic children compared to healthy children.
- Higher eoxin D₄/PA and LTE₄/PA ratios were observed in children with BHR.
- Children with chronic lung disease exhibited the highest ratios for 15-HETE/PA, LTC₄/PA, LTE₄/PA, and LTB₄/PA.
Conclusions:
- Childhood asthma is associated with increased activity of the 15-LO inflammatory pathway.
- Elevated eoxin levels in EBC, alongside increased 5-LO product LTC₄, are linked to asthma and BHR.
- These eicosanoid markers may offer potential therapeutic targets for asthma management.
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