Glycopeptide biosynthesis in the context of basic cellular functions
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Updated: Jun 8, 2026

The Application of Open Searching-based Approaches for the Identification of Acinetobacter baumannii O-linked Glycopeptides
Published on: November 2, 2021
Evi Stegmann1, Hans-Jörg Frasch, Wolfgang Wohlleben
1Interfakultäres Institut für Mikrobiologie und Infektionsmedizin Tübingen Mikrobiologie/Biotechnologie, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Abstract:
Using molecular genetics, biochemistry and organic chemistry the biosynthesis of glycopeptides has been elucidated in detail. It can be categorised in three parts: precursor supply, linking of the peptide backbone and modification reactions. The important steps of the biosynthesis are carried out at a multi-enzyme complex consisting of three non-ribosomal peptide synthetases (NRPS), three oxygenases and one halogenase. Novel derivatives can be generated by precursor-directed biosynthesis or combinatorial approaches and the knowledge can be used to optimise the yield of production by metabolic engineering approaches. To protect themselves glycopeptide producers seem to have developed strategies which may differ from those of the resistant pathogens.
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