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Updated: Jun 8, 2026

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
Published on: October 19, 2021
Piecewise affine systems approach to control of biological networks
Jun-Ichi Imura1, Kenji Kashima, Masami Kusano
1Department of Mechanical and Environmental Informatics, Graduate School of Information Science and Engineering, Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8552, Japan. imura@mei.titech.ac.jp
Abstract:
In terms of a piecewise affine system representation, which is a kind of hybrid system model, this article discusses a series of approaches to modelling, analysing and synthesizing a biological network such as a gene-regulatory network. First, the input assignment problem, the controllable state set problem (CSP) and the input trajectory generation problem are emphasized as control problems to be addressed for biological networks. Subsequently, after the modelling issue on biological networks developed in the systems and control community is briefly explained, the CSP is described in detail with reference to control of the quorum-sensing system in the pathogen Pseudomonas aeruginosa. Finally, an optimal control design method to the quorum-sensing system is proposed as a solution to the input trajectory generation problem.
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